In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging
Identifieur interne : 000F76 ( Main/Exploration ); précédent : 000F75; suivant : 000F77In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging
Auteurs : Chloé Chong [Suisse] ; Felix Scholkmann [Suisse] ; Samia B. Bachmann [Suisse] ; Paola Luciani [Suisse] ; Jean-Christophe Leroux [Suisse] ; Michael Detmar [Suisse] ; Steven T. Proulx [Suisse]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Techniques to image lymphatic vessel function in either animal models or in the clinic are limited. In particular, imaging methods that can provide robust outcome measures for collecting lymphatic vessel function are sorely needed. In this study, we aimed to develop a method to visualize and quantify collecting lymphatic vessel function in mice, and to establish an
Url:
DOI: 10.1038/srep22930
PubMed: 26960708
PubMed Central: 4785392
Affiliations:
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Bachmann</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich</institution>, 8093 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luciani, Paola" sort="Luciani, Paola" uniqKey="Luciani P" first="Paola" last="Luciani">Paola Luciani</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich</institution>, 8093 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leroux, Jean Christophe" sort="Leroux, Jean Christophe" uniqKey="Leroux J" first="Jean-Christophe" last="Leroux">Jean-Christophe Leroux</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich</institution>, 8093 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich</institution>, 8093 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T." last="Proulx">Steven T. Proulx</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich</institution>, 8093 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Techniques to image lymphatic vessel function in either animal models or in the clinic are limited. In particular, imaging methods that can provide robust outcome measures for collecting lymphatic vessel function are sorely needed. In this study, we aimed to develop a method to visualize and quantify collecting lymphatic vessel function in mice, and to establish an <italic>in vivo</italic> system for evaluation of contractile agonists and antagonists using near-infrared fluorescence imaging. The flank collecting lymphatic vessel in mice was exposed using a surgical technique and a near-infrared tracer was infused into the inguinal lymph node. Collecting lymphatic vessel contractility and valve function could be easily visualized after the infusion. A diameter tracking method was established and the diameter of the vessel was found to closely correlate to near-infrared fluorescence signal. Phasic contractility measures of frequency and amplitude were established using an automated algorithm. The methods were validated by tracking the vessel response to topical application of a contractile agonist, prostaglandin F2α, and by demonstrating the potential of the technique for non-invasive evaluation of modifiers of lymphatic function. These new methods will enable high-resolution imaging and quantification of collecting lymphatic vessel function in animal models and may have future clinical applications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G. Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K. Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zawieja, D C" uniqKey="Zawieja D">D. C. 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Michelassi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mchale, N G" uniqKey="Mchale N">N. G. McHale</name></author><author><name sortKey="Roddie, I C" uniqKey="Roddie I">I. C. Roddie</name></author><author><name sortKey="Thornbury, K D" uniqKey="Thornbury K">K. D. Thornbury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimizuka, K" uniqKey="Kimizuka K">K. Kimizuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, I" uniqKey="Choi I">I. Choi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Chong, Chloe" sort="Chong, Chloe" uniqKey="Chong C" first="Chloé" last="Chong">Chloé Chong</name></noRegion><name sortKey="Bachmann, Samia B" sort="Bachmann, Samia B" uniqKey="Bachmann S" first="Samia B." last="Bachmann">Samia B. Bachmann</name><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><name sortKey="Leroux, Jean Christophe" sort="Leroux, Jean Christophe" uniqKey="Leroux J" first="Jean-Christophe" last="Leroux">Jean-Christophe Leroux</name><name sortKey="Luciani, Paola" sort="Luciani, Paola" uniqKey="Luciani P" first="Paola" last="Luciani">Paola Luciani</name><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T." last="Proulx">Steven T. Proulx</name><name sortKey="Scholkmann, Felix" sort="Scholkmann, Felix" uniqKey="Scholkmann F" first="Felix" last="Scholkmann">Felix Scholkmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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